#AskAChemist: What’s the deal with fabric dyes?

This week on Ask A Chemist

Short answer:

Prince knows all

Longer answer:

Wool fibers are basically bundles of protein, specifically the protein alpha-keratin. All proteins are polymers of amino acids, have the general structure shown below.

Amino acid repeats (n) make up proteins. ‘R’ is shorthand for the variety for chemical groups that could be attached.

Protein fibers like wool respond really well to so-called “acid dyes”. The dyes aren’t acids, but the acid dye’s salt version. Let’s take a look at a real example of an acid dye, beautiful acid red 73!

acid red 73
acid red 73 structure (left) and powder (right)

See where the sodiums (Na) are? When there are hydrogens in those positions, acid red 73 is an acid.  With the sodiums there, it’s a salt. If we throw this salt in water, or a water-based solution, it’ll ionize to Na+ and dye-. The dye- is good, because we can make wool’s proteins have lots of positives spots for lots of dye- ions to stick to. See those ~NH~ groups in protein’s ? They can be protonated by an acid to become ~+NH2~. We can put wool in a water-based acid bath, add our dye salt, and let opposites attract*. Besides + and – hanging out, other intermolecular interactions keep the dye on the wool. Voilà! Chemistry! Dyed wool.

Dyed wool will do that to people.

What about cotton? Like wool fibers, cotton fibers are also polymers. Cotton’s monomers aren’t amino acids, but glucose. Cotton is a polysaccharide, specifically, cellulose (below).

Repeating glucose molecules make up cellulose.

See all those ~OH~ groups of cellulose? They can be deprotonated by a base to leave ~O-~. These negative sites are attractive to dye+, which we can get by dissolving basic dyes (actually salts) in water or water-based solutions. Gosh, this sounds familiar… yep, it’s like the wool process, but opposite charges. With cotton, the fiber is made negative with base and attracts dye+. Thing is, using basic dyes with cotton requires the use of a mordant – another chemical that helps keep on the dye on the cotton fiber. Without a mordant, basic dyes don’t stay put like we’d want and can come out in the wash. Fear not, a whole host of cellulose specific dyes that stay put and don’t require mordants have been designed by crafty chemists.

_______Additional References______

Aspland, J. R. (1993) The Application of Ionic Dyes to Ionic Fibers: Nylon, Silk and Wool and Their Sorption of Anions. Text. Chem. Color., 25, retrieved from

Aspland, J. R. (1997) Textile Dyeing and Coloration. Research Triangle Park: American Association of Textile Chemists and Colorists

Leon, N.H. (1972) Structural aspects of keratin fibres. J.  Soc. Cosmet. Chem., 23, retrieved from


Featured image was made by the author using PowerPoint

Prince gif from rampages

General protein structure from UCLA’s Illustrated Glossary of Organic Chemistry

Acid red 73 structure from Sigma-Aldrich and dye powder image from Nuoou Chem

Carton gif from thechive

Cellulose structure from

you’re welcome gif from tumblr

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DrRubidium is an analytical chemist that spends her days finding needles in needlestacks. Also a science communicator, she focuses on the the science behind everyday stuff and pop culture.

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